Evaluation of Sodium Diuresis Following Mannitol Infusion

Mechanism of increased renal sodium excretion following mannitol infusion in man.

Mannitol, when given intravenously to normal human subjects or animals, shares with a number of other substances the property of promoting an increased rate of renal excretion of sodium, chloride, and water. The generally accepted hypothesis concerning the mechanism of this action is that mannitol exerts its effect directly on the renal tubules. The osmotic pressure of the mannitol within the t...

Differences between Saline and Mannitol Diuresis in Hydropenic Man.

Differential renal function studies during mannitol diuresis in hypertension.

DIFFERENTIAL renal function studies during water diuresis were introduced by Howard and associates' in 1954 to aid in detection of hypertension secondary to unilateral renal disease. To enhance the diagnostic and prognostic value of such tests, many modifications in the conditions for their performance have been developed: Dustan and co-workers2 studied patients during osmotic diuresis with man...

Cyanide and thiocyanate concentrations following sodium nitroprusside infusion in man.

Twenty-six patients, receiving an infusion of sodium nitroprusside (SNP) during surgery, had considerable increases in both red cell and plasma cyanide concentration, but only small changes in plasma thiocyanate concentration. There was a linear relationship between both plasma and RBC cyanide concentrations and the total dose of SNP. The expired cyanide concentration followed the changes in th...

Incidence and Risk Factors for Acute Kidney Injury Following Mannitol Infusion in Patients With Acute Stroke

Mannitol, an osmotic diuretic, is commonly used to treat patients with acute brain edema, but its use also increases the risk of developing acute kidney injury (AKI). In this study, we investigated the incidence and risk factors of mannitol-related AKI in acute stroke patients.A total of 432 patients (ischemic stroke 62.3%) >20 years of age who were admitted to the neurocritical care center in ...